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Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

The Increlex label explicitly contraindicates use in patients with active or suspected neoplasia and notes that active or suspected malignancy should prompt discontinuation

The 12-week Phase IIb trial in 300 obese adults, with 1mg daily dosing, produced an average weight loss of 2.6 kg compared with 0.8 kg in the placebo group