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Safety and Tolerability Adverse event profiles are broadly similar across both compounds, consistent with what's expected from incretin-pathway agonists: Mazdutide: most common adverse events across trials were diarrhea (~36%), decreased appetite (~29%), nausea (~23%), and vomiting (~14%)

The NIHR 'Be Part of Research' portal and ClinicalTrials.gov list current recruitment opportunities for investigational obesity studies

Focus on nutrient-dense foods including lean proteins, whole grains, fruits, and vegetables

But relatively hard to eat less than we want. Food noise GLP-1 medications reduce hunger and the constant thoughts about eating that many patients describe as food noise. Ive had some patients say to me that they didnt even realize how constantly they were thinking about food throughout the day until they started the GLP-1 medication and that food noise was suddenly gone, Tronieri said