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Metabolic Resistance Point GLP-1 therapy is most strategically introduced when patients exhibit metabolic adaptations that counteract behavioral interventions: Plateau Effect: GLP-1 should be considered when patients adhering to a caloric deficit and exercise program experience a weight plateau, indicating a reduction in Total Daily Energy Expenditure (TDEE) as a physiological defense

"Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial"

Instead, hold the peptide vial at a slight angle, roughly 45 degrees

Treatment with 3 mg liraglutide for 20 weeks reduced appetite and energy intake, resulting in a significant weight loss (7.2 kg) in a large, RCT in people with obesity [15]