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In the central nervous system (CNS), GLP-1 and GLP-1R agonists are diffused into the cerebrospinal fluid (CSF) and the brain as demonstrated in rodent models (Wang et al., 2015), and increased GLP-1 concentration in the brain is thought to influence brain function in the hippocampus (Kastin et al., 2002
The body appears to recalibrate its cardiovascular response over time, potentially through downregulation of glucagon receptor sensitivity in cardiac tissue or compensatory autonomic adjustments
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10.1126/science.aav2588 143 LeuS
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