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A double-blind, placebo-controlled trial in 90 HIV-positive patients with symptomatic distal symmetrical polyneuropathy found no benefit of intramuscular injection with 1 g/day of ALCAR for two weeks in the intention-to-treat analysis, but there was some pain relief in the group of 66 patients who completed the trial (84)
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Consequently, the immune response necessitates subtle, context-tailored modulation to prevent excessive harm
Qureshi AA, Tan X, Reis JC, Badr MZ, Papasian CJ, Morrison DC, Qureshi N (2011) Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by -tocotrienol and quercetin
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