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Safety and tolerability are crucial, as prolonged or high doses can cause adverse effects, necessitating rigorous clinical trials and standardised formulations to ensure quality, potency, and stability
Empagliflozin in patients with chronic kidney disease
The FDA resumed review after the company submitted HOPE-3 data
However, these adaptive responses develop gradually and become evident only over longer periods 36 , whereas our experimental endpoint of 24 h represents an early stage in which such compensatory effects are likely negligible
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