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The GI Learning Curve: Why Your Gut is Reacting to GLP-1s To better understand why GLP-1 stomach discomfort (among other side effects) happens, its helpful to know how these medications work

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Local Common (1% to 10%): Injection site reactions (subcutaneous formulation) Injection site reactions included administration site reactions, application/instillation site reactions, erythema, induration, inflammation, infusion site reactions, injection site discomfort, injection site pruritus, injection site rash, and irritation