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The condition fragments sleep and becomes increasingly disruptive with age
Pharmacological modulators Among pharmacological modulators, the small-molecule HSP72 activator BGP-15 has shown notable promise in both preclinical studies and early-phase clinical trials
Freezing is equally destructive but in a different way
While the trials were negative clinically, presenters and discussants noted biomarker changes consistent with reduced neuroinflammation (e.g., decreases in highsensitivity CRP) and other Alzheimersrelated signalsmodest but statistically significant effects that did not yield measurable cognitive benefit
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