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It describes how disruption of the klotho gene in mice causes a phenotype that mimics many aspects of accelerated aging: short lifespan, osteoporosis, skin atrophy, arteriosclerosis, emphysema, infertility, etc
This indicated that, along with an overall decrease in TG synthesis, specific pathways/enzymes involved in polyunsaturated fatty acid (PUFA) synthesis may be stimulated in the livers of KO mice
When Choline is depleted in the body, fat metabolism and utilization may be decreased
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