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Unlike selective PDE1B or PDE10A inhibitors, which typically modulate either positive, negative, or cognitive symptoms, Zinc41306568 suppressed ketamine-induced hyperlocomotion (a model of positive symptoms), attenuated social isolation (negative symptoms), and improved recognition memory in the novel object recognition test (cognitive symptoms)

Availability of data and materials The data that support the findings are available from the Exercise and Biochemical Nutritional Laboratory (EBNL) in the Department of Human Performance of Baylor University and the grant sponsor, being the Function Research Group of Kyowa Hakko Bio Co., Ltd

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