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[9] According to NICE guidelines (NG28) , diabetes management should be individualised and any changes to treatment regimens should be made collaboratively between patient and clinician
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This osteogenic effect is mediated at least in part through the Transforming Growth Factor beta (TGF-) and SMAD signaling pathway
Both are designed to be started low and increased as needed: They use a gradual dose-increase schedule to improve tolerability and reduce side effects
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