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doi: 10.1016/j.cmet.2017.04.013 69 MoreiraGAzevedoFRibeiroLSantosAGuadagniniDGamaPet al

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A majority of committee members supported placing the substances on the 503A Bulks List, despite the FDA staffs initial proposals against inclusion

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Moving forward, the results of the phase 3 SURPASS clinical trial program demonstrated that tirzepatide was as effective and safe as other anti-diabetic agents, such as semaglutide and dulaglutide (SURPASS-2) (SURPASS J-mono), long-acting insulin analogs (degludec and glargine) (SURPASS-3,4), and placebo (SURPASS-1) (SURPASS-5), in managing T2DM diabetes [65,66,67,68,69]

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