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Significant barriers still exist despite established safety profiles, such as high costs that restrict access worldwide, a lack of predictive biomarkers for treatment response, a lack of knowledge about the mechanistics of gut microbiota interactions, and an incomplete understanding of long-term safety, particularly with regard to thyroid and pancreatic effects
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They may be bundled with whatever procedure is being provided (if it involves IV lines)
Some have pulled back or canceled their coverage of the drugs after initially offering it
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