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2e) Since the diagnosis of T2D relies primarily on exclusion, the clinical phenotype varies widely
In Olsons case, genetic testing revealed multiple biological drivers interfering with her hunger and satiety signals
The cumulative fractional labeling from palmitate and glucose in DKO cell histone acetylation matches that by WT and ACSS2 KO cells, while ACLY KO cells have much lower cumulative labeling from these two sources, consistent with unlabeled acetate feeding the acetyl-CoA pool only in those cells (Supplemental Figure 5D)
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