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Patients were maintained on a stable dose of MET
Because creating glutathione and fighting ROS is highly energy-dependent, the immune system consumes massive amounts of the host's ATP
Instead, by improving metabolic regulation and reducing chronic inflammatory stress, GLP-1 signaling may alter the cellular environment in ways that support more effective management of accumulated molecular damage
Interestingly, weight loss generally reduces GERD severity over time, so while early GI effects of tirzepatide may transiently worsen symptoms, long-term weight reduction might ultimately improve reflux for many patients
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