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Description

JAMA (2023) 330(12):1127

The substance was cobalamin, which the discoverers called "vitamin B 12 "

Competitive association kinetics TR-FRET was monitored on simultaneous addition of four or more concentrations of unlabeled agonist plus 10 nM exendin-4-FITC to CHO-SNAP-GLP-1R cells labeled with Lumi4-Tb and pre-incubated with metabolic inhibitors

However, the authors urge caution in interpreting these findings due to the limited number of trials, the variations in study designs, and the heterogeneity in patient populations and substance types studied