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Those conclusions require product-specific pharmacokinetic, pharmacodynamic, and human safety data [13] [14]
Safety and effectiveness in pediatric patients has not been established
Identification of individuals at risk for postoperative cognitive dysfunction (POCD)
Additionally, mtDNA damage has been associated with PD etiology and progression (Tresse et al., 2023) and mitochondrial dysfunction is linked genetically to PD, since many mutations associated to familial cases of PD were found in genes such as PINK1 or PARKIN, which regulate mitochondrial turnover (Valente et al., 2004
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