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Graphical Abstract Similar content being viewed by others Introduction The world's climate has changed dramatically over the last decades, due to both natural and anthropic factors, even if it has been observed that natural factors determined a smaller impact than anthropogenic factors (Lalay et al
Potential Interactions Between GLP-1 Drugs and Thyroid Conditions Understanding potential interactions between GLP-1 receptor agonists and thyroid conditions requires consideration of both pharmacological mechanisms and clinical monitoring implications
mean hip circumference was 100 cm
These growth abnormalities in LS patients without IGF-I substitutive treatment includes postnatal average growth rates of one-half the expected during the first years of life[19], a small brain (with prominent forehead, reduced vertical dimension of the face and hypoplasia of the midfacies and the nasal bridge), a small heart and acromicria[203] together with underdevelopment of the muscular system that delays walking in three-fourth of patients[204, 205], osteopenia at all stages (despite normal sex hormone status) with increased occurrence of avascular necrosis of the femoral head[206], impair and weaken skin, hair and nail growth[207], blue sclera due to the decreased thickness of its connective tissue, allowing visualization of the underlying choroid[205], a puberty delay from 3 to 7 years[206], retardation in the maturation of dentition[206] and high-pitched voice[208]
