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We identify mitochondrial trifunctional protein- (MTP) as a binding partner of GLP-1(2836) and demonstrate that the ability of GLP-1(2836) to shift substrate utilization from oxygen-consuming fatty acid metabolism toward oxygen-sparing glycolysis and glucose oxidation and to increase cAMP levels is dependent on MTP
By week 4 at 0.25 mg, weight loss is minimal, typically 1, 2 lbs
We then compared the effects of the two treatments on these pathological processes
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