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One hundred and forty-four AE signals showed statistically significant signals suggesting a potential association with tirzepatide, with several new including postmenopausal haemorrhage and menstrual disorder (implying regulatory interference on sex hormones), Wernickes encephalopathy and sleep disorder (malnutrition caused by low intake)
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The loss of pigment in hair shafts because of decreased melanocyte function is typically known as graying, or going gray, although the exact cellular and molecular mechanisms are not yet completely understood
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