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102 Furthermore, inhibiting DDR-related posttranslational modifications, such as ATM/ATR-dependent phosphorylation or ubiquitination cascades, can selectively impair tumor cell repair fidelity without disrupting normal cells
An important point in the context discussed is that, since aging is an extremely complex phenomenon involving multiple pathways and operating at various levels of the biological organization of a living system, it can hardly be accurately measured with a single biomarker
doi:10.1080/14740338.2019.1636964
The BDNF gene is also important in this process because it helps regulate neuron survival and new neural connections
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