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While there have been isolated reports of mood changes or depressive symptoms in some individuals, these cases are rare and often involve patients with pre-existing psychiatric conditions. So far, the existing studies dont find a significant increase in psychiatric adverse events compared to placebo
86 DRAM1 participates in the regulation of autophagy and apoptosis in intestinal epithelial cells by positively regulating JNK, and knockdown of DRAM1 can lead to a decrease in the phosphorylation levels of c-Jun and JNK, inhibit the formation of autophagosomes, and alleviate the symptoms of UC
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The Phase II trial for retatrutide reported some adverse events: A large percentage of participants (73% to 94%) reported side effects while taking retatrutide, especially in the higher 8-mg and 12-mg groups
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