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GLP-1 receptor agonists slow gastric emptying, meaning food remains in the stomach for longer periods
Each transition added clinical benefit, reset the Orange Book patent clock, and extended Vertexs effective monopoly over the CFTR modulator category
Since then, new generations, like liraglutide in 2010, once-weekly dulaglutide in 2014, and oral semaglutide in 2019, have arrived roughly every few years, each improving convenience, potency, and durability
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