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For patients who need both Toujeo specifically (the U-300 concentration) and a GLP-1 agonist, separate injections are currently the only option, as there is no combination product using the U-300 concentration
In clinical trials of tirzepatide, they seemed to be slightly more common with higher doses of the drug
But glucagon receptors are also expressed in cardiac tissue, where their activation has two well-documented effects: A positive chronotropic effect increasing heart rate and a positive inotropic effect increasing the force of heart contractions
That idea is an extrapolation from rat data
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