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A 2019 meta-analysis by Huang and Cheng (JAMA Dermatol) found no statistically significant increase in depression risk with isotretinoin versus other acne treatments (pooled OR 0.98, 95% CI 0.84 to 1.15) [15]

While both options are highly effective, the primary difference lies in how they interact with your bodys metabolic receptors

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But the decisive part was his concept of aesthetics : not as much mass as possible, but deliberately shaping the areas that create the classic V-taper