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It can be viewed as essential therapy or as an optional intervention, depending on indication
Pharmacokinetic study Plasma agonist concentration after a single IP injection (24 nmol kg 1 ) was measured with an exendin-4 C-terminus-specific ELISA (Phoenix Pharmaceuticals), a peptide region that does not differ between agonists, hence equally detecting exendin-4 and exendin-phe1 (confirmed by analysis of known concentrations of each agonist)
Toxicology 200:193203 Cereghetti GM, Stangherlin A, de Brito OM et al (2008) Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria
