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Clathrin-mediated endocytosis (CME) usually requires arrestin to act as a scaffolding protein to link the receptor to the 2-adaptin subunit of adapter protein 2 (AP2), which then targets the receptor to clathrin-coated pits (Kaksonen and Roux, 2018)
At the higher end, 2.4 mg requires 120 units, which exceeds the capacity of a standard 100-unit insulin syringe
But the good news
It is common to get different injection pens with higher doses as you move along your weight loss journey
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