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While GI side effects have been suggested to be involved in mediating the weight-loss effect of GLP-1RAs, analysis of large clinical trial data sets with liraglutide and semaglutide has shown that, while GI side effects may lead to more initial weight loss, they are not the mechanism of weight loss as many patients have weight loss and no side effects (182, 183)
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Lancet 402 (10400), 472483
While you may not see a change on the scale immediately, internal shifts are happening from the moment of the first injection
