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Taken together, these HSF/HSP members differ in both reproductive relevance and evidence strength, with some supported by established spermatogenic roles and others remaining preliminary biomarker or therapeutic candidates (Table 1)

Clinical and subjective measures Depression Depressive symptoms were assessed with the clinician-rated MontgomeryAsberg Depression Rating Scale (MADRS) as the primary measure, together with the self-report Quick Inventory of Depressive SymptomatologySelf Report (QIDSSR) and the Maudsley 3-item Depression Visual Analogue Scale (M3VAS)

In addition, a few antiepileptic drugs, such as the short branched-chain fatty acid valproate, can also enter the brain through carrier-dependent active transport (47, 48)

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