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Concurrent impairment of Nrf2 signaling reduces antioxidant capacity, establishing a feed-forward loop characterized by progressive ROS accumulation, mitochondrial dysfunction, and muscle fiber degeneration
Prominent mid-sized biopharma firms such as Zealand Pharma, Viking Therapeutics, and Structure Therapeutics have become major beneficiaries of this trend, advancing innovative compounds that promise to complement or outperform current GLP-1 therapies
These canonical functions positioned mGPDH as a redox-linked metabolic enzyme long before its recent recognition as a ferroptosis regulator via ubiquinol (CoQ 10 H 2 )-dependent antioxidant defense
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