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Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal
The academic neuroscientist Paul Kenny, from the Icahn School of Medicine at Mount Sinai, in New York, said the world was in the midst of a huge experiment as millions of people started using GLP-1 drugs, with researchers only now starting to collect data on how they affect behaviour as well as physiology
One review notes that while berberine may have some promise, its not proven to safely or consistently raise GLP-1 in people, and higher-quality research needs to be performed
The OASIS 4 clinical trial published in the New England Journal of Medicine in 2025 followed adults with overweight or obesity for 71 weeks
