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In addition to the docking score and the RMSD of GSSG, we also considered the S-S distance between GSSG and each cysteine residue in GLRX, as a short distance is required for the consequent glutathionylation process
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They include those for transporting transferrin, LDL (low density lipoprotein), insulin, etc., with transferrin receptor-mediated endocytosis being the most investigated and successful one for developing a brain targeting agent
Recent advances in the knowledge of cancer biology led to the development of a new diagnostic and therapeutic arsenal that is not limited to selective target drugs but also includes already existing drugs that are multi-targeted or used in polypharmacology ( Drug repositioning is considered for several types of cancer
