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Supplemental Table 3
The main advantage of these systems is a direct contact between the barrier cells (Gastfriend et al., 2018)
Phase 3 trials are large-scale studies designed to: Confirm efficacy in a broader population Monitor safety at scale Compare against placebo or standard treatment Identify uncommon adverse effects Assess long-term outcomes Only after successful completion of Phase 3 trials can a manufacturer submit data to regulatory authorities such as the European Medicines Agency and, subsequently, the Health Products Regulatory Authority
El Aita I, Rahman J, Breitkreutz J, Quodbach J (2020) 3D-Printing with precise layer-wise dose adjustments for paediatric use via pressure-assisted microsyringe printing
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