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Their results demonstrate that GLP-1, through an unknown mechanism, can preserve axonal and neurofilament structure despite the induction of progressive neurotoxicity, thus illustrating neuroprotective properties that can be leveraged against disorders in the central nervous system [60]
Nature 535 (7612), 376381
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To summarize, age-related changes in mitochondria, antioxidant gene expression, and epigenetic regulation progressively lead to redox imbalance in oocytes, compromising their metabolic competence and genomic integrity
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