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That selectivity makes it useful for isolating MC4R-mediated signalling G-protein-coupled cAMP and phospholipase-C cascades, intracellular calcium flux and ERK/MAPK activation in neuronal and receptor-expressing models

Intracellular iron concentration also showed a dose-dependent increase at 72 h, as demonstrated by ICP-MS analysis

Key References Pi-Sunyer X, Astrup A, Fujioka K, et al

In this off-target interaction, the triazole nitrogen engages the conserved glutamine residue, and the carboxamide side chain projects into a narrow lipophilic channel