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2018 RCT is well-designed and positive - and it's not the final word

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Unfortunately, with bariatric surgery representing a notable exception, most conventional weight loss modalities (dietary- and physical activity-based interventions) are found to provide highly patient-specific, short-term weight benefits that rarely persist for more than a few months and may involve significant alternations to patients' daily routines

SETTLE 46 and LINCS 47 constraints were applied on the hydrogen-involved covalent bonds in water and other molecules, respectively, and the time step was set to 2 fs