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These represent indirect mechanisms rather than direct drug effects
Zhang N, Wu J, Wang Q, Liang Y, Li X, Chen G, et al
As a large protein (approximately 27 kDa), it cannot be synthesized by peptide compounding methods and requires either gene therapy delivery or cell-based manufacturing
The mechanisms that drive this association include systemic inflammation, endothelial dysfunction, oxidative stress, hypertension, and metabolic dysfunction
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