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Here, we confirm the GIPR antagonist and GLP-1R agonist activities in cell-based systems and report the ability of AMG 133 to reduce body weight and improve metabolic markers in male obese mice and cynomolgus monkeys
Glucagon-like peptide-1 (GLP-1) agonists are an increasingly common treatment for diabetes and obesity in the United States
The team studied the rats' brains to see where GLP-1 was influencing thirst
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