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During autophagosome formation, DHHC7-mediated palmitoylation of autophagy-related protein 16-like protein 1 (ATG16L1) at Cys153 specifically enhances its binding to WD repeat domain phosphoinositide interacting 2B (WIPI2B) and RAB33B, a member of the RAS oncogene family (RAB33B) [15], which ensures efficient recruitment of the microtubule-associated protein 1 light chain 3 (LC3) lipidation machinery to the phagophore [136, 137]
Discussion In summary, this study reports on the rational design, synthesis, and in-depth biological evaluation of tumor-targeting ruthenium containing nanoreactors for glutathione oxidation catalysis in osteosarcoma cells with a 1% O 2 atmosphere
Simultaneously, it modulates expression of matrix metalloproteinases that clear damaged tissue
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