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While ROS induction appears to be essential for b-AP15-mediated DR5 expression and the sensitisation to TRAIL, further studies are required to confirm if the downregulation of SOD2 is the causal factor in the accumulation of ROS induced by b-AP15 in HNSCC cells
Participants were male and female adults aged 18 years who were of non-childbearing potential and met the BMI inclusion criteria of either 30.0 kg/m, or 27.0 kg/m with hypertension or dyslipidemia
Recently, the tyrosine kinase activity of EGFR has become a prime therapeutic target in PCa treatment
& Gatenby, R
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