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Published literature has examined how alterations in NNMT activity influence measurable biochemical parameters, including nicotinamide-derived metabolites and downstream metabolic signaling pathways under controlled laboratory conditions

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Quantitative analysis of collagen development as well as granulation tissue formation and angiogenesis was performed in vivo models, incisional skin wounds, coloncolon anastomoses, and synthetic sponge implants (Seiwerth et al., 1997)