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In Long COVID and ME/CFS, the NF-B pathway is often chronically activated, driving the continuous release of inflammatory cytokines like Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-)
K + efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter
doi:10.1056/NEJMoa2307563 Marso SP, Bain SC, Consoli A, et al
One possible explanation for this relationship is that oxidants generated by phagocytosing macrophages may diffuse into the extracellular medium, where they pose an oxidative threat to G6PD-deficient erythrocytes
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