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On a cellular level, B12 serves as an essential cofactor for two key enzymatic reactions involving methionine synthase and methylmalonyl-CoA mutase
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Sheng J, Wu Y, Ding H, Feng K, Shen Y, Zhang Y, et al
The combination of this particular class with thiazolidinediones presents an interesting concept, currently under trial in a phase-4, open-label study, where empagliflozin is being evaluated alone and in conjunction with pioglitazone on diabetic patients, with the primary outcome being the measurement of liver fat content by MRI-PDFF (NCT03646292)
