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Weight loss results vary significantly by specific medication and dose: Semaglutide 2.4 mg (Wegovy): Clinical trials (STEP program) showed average weight reductions of 1517% at 68 weeks Tirzepatide (Zepbound): SURMOUNT trials demonstrated weight reductions of 1522% at 72 weeks, with results varying between populations with and without diabetes Liraglutide 3 mg (Saxenda): Typically produces 510% weight loss over 56 weeks The rate of weight loss is not linear
Peer review Peer review information Nature Reviews Rheumatology thanks Helena Marzo-Ortega, who co-reviewed with Jacob Williams
For postpartum women, this is complicated by the fact that nausea can overlap with sleep deprivation effects, hormonal fluctuation, and the general physical demands of new parenthood
