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Here, we use a pooled, dual CRISPR screening strategy that knocks out pairs of transporters in four metabolic states glucose, galactose, OXPHOS inhibition, and absence of pyruvate designed to unmask the inter-dependence of these genes

Unlike natural GLP-1, which breaks down in 1-2 minutes, the modified peptide has a longer half-life, ranging from hours to days

[1,2] When overweight categories are included, the burden becomes even more striking: since 2022, approximately 40% of Canadian men and 30% of women are classified as overweight, meaning that nearly three in four men and two in three women fall within BMI ranges associated with increased health risk

Taking into account the effects on embryo development in Sel-Plex sows, this regulation of Se-GSH-Px might have been important for the subsequent steps of the ovulation process and eventually for the quality of conceptuses