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FEBS Lett 592(5):679

Ask your doctor which indication gives you the clearest path to coverage

Thyroid evidence boundary Jastreboff 2023 ( NEJM , NCT04881760), Rosenstock 2023 ( Lancet , NCT04867785), Sanyal 2024 ( Nature Medicine , NCT04881760), and the posted TRIUMPH-1 and TRIUMPH-4 toplines did not publish targeted Free T3, Free T4, or TSH outcomes

The main concerns include additive gastrointestinal effects (nausea, vomiting, diarrhoea), cognitive side effects from topiramate (difficulty concentrating, memory problems), and potential for excessive weight loss