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Combined GHRH + GHRP/ghrelinmimetic administration produces synergistic, amplified GH pulses compared to either agent alone [1] [2]
These include aberrant DNA methylation at imprinted genes and metabolic regulators, histone retention or abnormal post-translational modifications, and changes in small non-coding RNAs (e.g., miRNAs and tsRNAs) [206]
Therefore, PFKB enhances PFK1 activity and glycolysis by increasing F2,6BP production [145]
Acta 1862 , 506510 (2016)
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