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in Nature Medicine demonstrated that blocking NNMT in white adipose tissue increased energy expenditure, reduced fat mass, and improved insulin sensitivity in animal models even without changes in diet or activity (Kraus et al., Nature Medicine )
No phase II or III randomised controlled trials have been registered with the EMA, MHRA or FDA
[2,9] Studies show improved outcomes in models of peripheral nerve injury, traumatic brain injury, and spinal cord damage
In a presented study, it was reported that the SOD activity decreased in epilepsy patients 26
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