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New clues to genetics of depression are game-changing Acetyl-L-carnitine levels were also lower among those patients reporting a childhood history of abuse, neglect, poverty, or exposure to violence

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Mechanistically, ALC exerts its antidepressant effects via multiple pathways, including enhancement of mitochondrial function, upregulation of brain-derived neurotrophic factor (BDNF), modulation of glutamatergic neurotransmission, and epigenetic regulation of gene expression involved in mood regulation

Access this article Similar content being viewed by others Data availability The data used during the current study are available from the online databases such as DrugBank