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Glucagon-like peptide-1 (GLP-1) receptor agonists, including semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), and dulaglutide (Trulicity), along with tirzepatide (Mounjaro, Zepbound)a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonistare effective medications for type 2 diabetes and weight management
In the SURMOUNT-1 trial, tirzepatide showed significant weight loss results in adults without diabetes over 72 weeks (15-21% body weight reduction, depending on dose), while orlistat typically produces more modest results (approximately 3-5% additional weight loss beyond placebo at 1 year)
I went from 220 lbs to 170 lbs!" Alexandra Rodriguez, Vancouver, WA "I was initially skeptical about Semaglutide, but taking the leap was the best decision I've made
Favero G, et al
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